王琳琳
王琳琳

姓名:王琳琳
職稱/頭銜:碩士
所屬科室:生殖免疫科
從業年限:
技術專長:早孕期免疫細胞對胚胎的耐受機制,以及免疫細胞在複發性流產患者中的調控機制

個人簡介

  暨南大學碩士,深圳中山泌尿外科醫院生殖醫學臨床研究中心研究實習員,長期從事不孕症及生殖障礙相關診療策略研究,主要研究方向為感染、免疫、代謝與生殖障礙研究,具有豐富的醫學基礎科研背景。

  研究內容:

  從事不孕症及生殖障礙相關診療策略研究,主要研究方向為感染、免疫、代謝與生殖障礙研究。

  學術成果:

  主持或參加科研項目(課題)及人才計劃項目情況(按時間倒序排序):

  1. 深圳市科技創新委基礎研究項目、JCYJ20190813161010761、滋養層細胞與母胎界面巨噬細胞極化的相互作用及機制研究、2020/08-2023/08、58 萬,在研、參與。

  2. 廣東省自然科學基金面上項目、2019A1515011315、IGF-1 通過上調子宮基質細胞丙酮酸激酶的表達促進蛻膜化的機制研究、2019/10-2022/09、25 萬,在研、參與。

  3. 國家自然科學基金面上項目、21577049、三苯基錫酶催化轉化的量子特性和分子機制、2016/01-2019/12、78 萬,結題、參與。

  4. 廣東省省級科技計劃項目、2014A020216013、水體有機錫和多溴聯苯醚複合污染處理菌劑與處理技術、2015/05-2017/04、20 萬,結題、參與。

  一、期刊論文

  1. 第一作者或通訊作者論文

  (1) Linlin Wang#, Longfei Li#, Chunyu Huang, Lianghui Diao, Ruochun Lian, Yuye Li, Shan Xiao, Xiuyu Hu, Meilan Mo* and Yong Zeng*. Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro fertilization treatment. Fertility and sterility. 2019, 112(2):250-257. (#: co-first author)

  (2) Longfei Li#, Linlin Wang#, Chunyu Huang, Lianghui Diao, Yongnu Zhang, Xu Zhang, Jian Xu and Yong Zeng*. Chronic hepatitis B infection alters peripheral immune response in women with reproductive failure. American Journal of Reproductive Immunology. 2019, 81(3): e13083. (#: co-first author)

  (3) Linlin Wang, Wenying Yi, Jinshao Ye*, Huaming Qin, Yan Long, Meng Yang, Qusheng Li. Interactions among triphenyltin degradation, phospholipid synthesis and membrane characteristics of Bacillus thuringiensis in the presence of d-malic acid. Chemosphere. 2017, 169:403–412.

  (4) Linlin Wang, Jinshao Ye*, Huase Ou, Huaming Qin, Yan Long, Jing Ke. Triphenyltin recognition by primary structures of effector proteins and the protein network of Bacillus thuringiensis during the triphenyltin degradation process. Scientific reports. 2017, 7(1): 4133.

  (5) Linlin Wang, Litao Tang, Ran Wang, Xiaoya Wang, Jinshao Ye*, Yan Long*. Biosorption and degradation of decabromodiphenyl ether by Brevibacillus brevis and the influence of decabromodiphenyl ether on cellular metabolic responses. Environmental Science and Pollution Research. 2016, 23:5166–5178.

  2. 既非第一作者又非通訊作者論文

  (1) Su Liu, Meilan Mo, Shan Xiao, Longfei Li, Xiuyu Hu, Ling Hong, Linlin Wang, Ruochun Lian, Chunyu Huang, Yong Zeng, Lianghui Diao. Pregnancy outcomes of women with polycystic ovary syndrome for the first in vitro fertilization treatment: A retrospective cohort study with 7678 patients. Frontiers in Endocrinology. June 08, 2020. DOI: 10.22541/au.159164145.55272265.

  (2) Lianghui Diao, Songchen Cai, Chunyu Huang, Longfei Li, Shuyi Yu, Linlin Wang, Su Liu, Yuye Li*, Yong Zeng*. New endometrial immune cell-based score (EI-score) for the prediction of implantation success for patients undergoing IVF/ICSI, Placenta (2020), doi: https://doi.org/10.1016/j.placenta.2020.07.025.

  (3) Litao Tang, Linlin Wang, Huase Ou, Qusheng Li, Jinshao Ye*, Hua Yin*. Correlation among phenyltins molecular properties, degradation and cellular influences on Bacillus thuringiensis in the presence of biosurfactant. Biochemical Engineering Journal. 2016, 105: 71–79.

  (4) Huase Ou, Juan Liu, Jinshao Ye*, Linlin Wang, Naiyun Gao, Jing Ke. Degradation of tris(2-chloroethyl) phosphate by ultraviolet-persulfate: Kinetics, pathway and intermediate impact on proteome of Escherichia coli. Chemical Engineering Journal. 2017, 308: 386–395.

  (5) Jinshao Ye, Juan Liu, Huase Ou*, Linlin Wang. Degradation of ciprofloxacin by 280 nm ultraviolet-activated persulfate: Degradation pathway and intermediate impact on proteome of Escherichia coli. Chemosphere. 2016, 165: 311–319.

  (6) Jiawen Ma, Litao Tang, Hua Yin, Linlin Wang, Xiruo Wang, Jinshao Ye*. Triphenyltin degradation and its correlation with cellular ion release by Bacillus cereus. Source Journal of Bioremediation. 2014, 1: 1–9.

  (7) Jinshao Ye*, Hua Yin, Hui Peng, Jieqiong Bai, Danping Xie, Linlin Wang, Biosorption and biodegradation of triphenyltin by Brevibacillus brevis. Bioresource Technology. 2013, 129: 236–241.

  二、會議摘要

  (1) Linlin Wang, Longfei Li, Juanhua Wu, Cong Chen and Yong Zeng*. Higher macrophages infiltration is correlated with poor outcome in early pregnancy. American Journal of Reproductive Immunology. Shanghai, China. 2018, 80 S1 P27.

  (2) Longfei Li, Linlin Wang, Yuanchang Zhu, Cong Chen, Juanhua Wu and Yong Zeng*. Human placental Hofbauer cells are markedly decreased in spontaneous miscarriage. American Journal of Reproductive Immunology. Shanghai, China. 2018, 80 S1 P13.

  (3) Longfei Li, Linlin Wang, Chunyu Huang, Juanhua Wu, Yaya Wu and Yong Zeng*. Immune profiles in the endometrium during implantation window and in the decidua of early pregnancy. Journal of Reproductive Immunology. 2018, 128: 57.

  (4) 王琳琳,葉錦韶*. D-蘋果酸對蘇雲金芽孢桿菌代謝及三苯基錫降解的作用機制. 第八屆全國環境化學大會,中國廣州,2015. (口頭報告)

  (5) Jinshao Ye and Linlin Wang. Relattion among Triphenyltin Recognition, Degradation, Ion Metabolism and Effective Proteins of Bacillus thuringiensis. The 8th International Conference on Environmental Science and Technology. Houston, Texas, USA–June 6–10, 2016.

  (6) Litao Tang, Wenying Yi, Linlin Wang, Jinshao Ye*. Cellular metabolism responses of Bacillus thuringiensis during triphenyltin biodegradation process. The 1st International Conference on Environmental Pollution and Health. Guangzhou, China. 2015, 6: 2–4.

  三、授權專利

  (1) 葉錦韶;王琳琳. 一種雙層電泳膠染色裝置和自動化電泳膠染色裝置、ZL 2018 2 1131681.5、2019-02-01、實用新型。