刁梁輝
刁梁輝

姓名:刁梁輝
職稱/頭銜:副院長/生殖醫學臨床研究中心主任
所屬科室:生殖醫學臨床研究中心/生殖免疫中心
從業年限:
技術專長:子宮內膜接受性的生物標記物篩選,子宮內膜微環境的免疫學調控機制及反覆胚胎着床失敗的臨床干預策略

個人簡介

  中山大學博士,德國漢堡大學博士后。深圳中山泌尿外科醫院生殖醫學臨床研究中心主任,錦欣醫療科技創新中心CEO,德國漢堡大學附屬艾本德醫院(UKE)母胎醫學客座科學家。擅長領域:生殖免疫代謝、子宮內膜微環境及臨床干預策略。社會任職:美國生殖免疫協會(ASRM)獲獎委員會委員,中國免疫學會會員,廣東省免疫協會生殖免疫專業委員會委員,《中華生殖與避孕雜誌》通訊編委,《Seminars in Immunopathology》《Journal of Reproductive Immunology》和 《American Journal of Reproductive Immunology》審稿專家。

  研究方向:

  1、複發性流產和反覆種植失敗患者子宮內膜容受性標記物篩選;2、妊娠早期免疫代謝重編程對妊娠的建立及維持的機制;3、圍着床期子宮內膜微環境的免疫調控機制及臨床干預策略。

  學術成果:

  主持或參加科研項目(課題)及人才計劃項目情況(按時間倒序排序):

  1、 深圳市自然科學基金、JCYJ20190813161801676、母胎界面DC細胞和T細胞代謝功能適應性調節的分子機制、2020/08-2023/08,20萬,在研,主持。

  2、 國家自然科學基金青年項目、81701529、HIF-1α與雌激素協同調控Tregs功能和子宮內膜微環境的機制研究、2018/01-2020/12,20萬,在研、主持。

  3、 廣東省科技發展專項資金項目、2017A020214006、子宮駐留調節性T細胞參與調控免疫微環境和胚胎種植的機制研究、2017/01-2019/12,30萬,結題,主持。

  4、 默克雪蘭諾--中國生殖醫學研究基金、hCG對母胎界面Treg聚集的調控及其與反覆種植失敗的相關性研究、 2016/01-2017/12、20萬,結題、主持。

  5、 深圳市科技創新委基礎研究項目、JCYJ20140415114504394、Treg在種植窗期活化遷移的調控因素及其信號通路、2014/09-2016/09、20萬,結題、主持。

  代表性研究成果和學術獎勵一、期刊論文

  1. 第一作者或通訊作者論文

  (1) Su Liu(#), Meilan Mo, Shan Xiao, Longfei Li, Xiuyu Hu, Ling Hong, Linlin Wang, Ruochun Lian, Chunyu Huang, Yong Zeng* and Lianghui Diao*. Pregnancy outcomes of women with polycystic ovary syndrome for the first in vitro fertilization treatment: A retrospective cohort study with 7678 patients. Front. Endocrinol. | doi: 10.3389/fendo. 2020. 575337

  (2) Diao, Lianghui(#), Songchen Cai(#), Chunyu Huang, Longfei Li, Shuyi Yu, Linlin Wang, Su Liu, Yuye Li(*), and Yong Zeng(*). New Endometrial Immune Cell-Based Score (Ei-Score) for the Prediction of Implantation Success for Patients Undergoing IVF/ICSI, Placenta (2020) 99, 180-188.

  (3) Diao, Liang-Hui,Li, Guan-Gui,Zhu, Yuan-Chang,Tu, Wen-Wei,Huang, Chun-Yu , Lian, Ruo-Chun,Chen, Xian,Li, Yu-Ye,Zhang, Tao,Huang, Yong,Zeng, Yong(*), Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells, Am J Reprod Immunol,2017.01.03,77(3):e12618

  (4) Ding, Jin-Li(#) ,Diao, Liang-Hui(#) ,Yin, Tai-Lang,Huang, Chun-Yu ,Yin, Biao, Chen, Cong,Zhang, Yi,Li, Jie,Cheng, Yan-Xiang,Zeng, Yong(*),Yang, Jing(*),Aberrant expressions of endometrial Id3 and CTLA-4 are associated with unexplained repeated implantation failure and recurrent miscarriage,Am J Reprod Immunol,2017.2.21,77: e12632

  (5) Wang, Kai(#) ,Diao, Liang-Hui(#) ,Gong, Yu,Liu, Xin,Li, Yingqiu(*),NEMO differentially regulates TCR and TNF-alpha induced NF-kappaB pathways and has an inhibitory role in TCR-induced NF-kappaB activation.,Cell Signal,2012.8.01,24(8): 1556~1564

  2. 既非第一作者又非通訊作者論文

  (1) Xu, Yanhong, Jie Mei, Lianghui Diao, Yuye Li, and Lijun Ding(*). Chronic Endometritis and Reproductive Failure: Role of Syndecan‐1. American Journal of Reproductive Immunology 84, no. 3 (2020): e13255.

  (2) Chen, Xian, Lianghui Diao, Ruochun Lian, Lingbin Qi, Shuyi Yu, Su Liu, Shenglai Lin, Zhigang Xue(*), and Yong Zeng(*). "Potential Impact of Maternal Vitamin D Status on Peripheral Blood and Endometrium Cellular Immunity in Women with Recurrent Implantation Failure." American Journal of Reproductive Immunology (2020): e13243.

  (3) Liu, Su(#), Hongxia Wei(#), Yuye Li, Lianghui Diao, Ruochun Lian, Xu Zhang, and Yong Zeng(*). "Characterization of Dendritic Cell (Dc) 10 in Recurrent Miscarriage and Recurrent Implantation Failure." Reproduction 1, no. aop (2019).

  (4) Wang, Linlin(#), Longfei Li(#), Chunyu Huang, Lianghui Diao, Ruochun Lian, Yuye Li, Shan Xiao, et al. "Maternal Chronic Hepatitis B Virus Infection Does Not Affect Pregnancy Outcomes in Infertile Patients Receiving First in Vitro Fertilization Treatment." Fertility and sterility 112, no. 2 (2019): 250-57. e1.

  (5) Zhu, Yuanchang, Qing Liu, Meijian Liao, Lianghui Diao, Tonghua Wu, Weijie Liao, Ziqiang Wang, et al. "Overexpression of Lncrna Epb41l4a-As1 Induces Metabolic Reprogramming in Trophoblast Cells and Placenta Tissue of Miscarriage." Molecular Therapy-Nucleic Acids 18 (2019): 518-32.

  (6) Thiele Kristin, Diao, Liang-Hui, Arck, Petra(*), Immunometabolism, pregnancy, and nutrition, Seminars in immunopathology, 2017, pp. 1-18.

  (7) Liu, Su, Diao, Liang-Hui, Huang, Chunyu , Li, Yuye, Zeng, Yong, Kwak-Kim, Joanne. The role of decidual immune cells on human pregnancy, Journal of reproductive immunology 124 (2017) 44-53.

  (8) Chen, Xian(#),Yin, Biao(#),Lian, Ruo-Chun,Zhang, Tao,Zhang, Hong-Zhan,Diao, Liang-Hui,Li, Yu-Ye,Huang, Chun-Yu ,Liang, De-Sheng(*),Zeng, Yong(*),Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage., Am J Reprod Immunol,2016.12.01,76(6):432~438

  (9) Huang, Chunyu(#),Zhang, Hongzhan(#),Chen, Xian,Diao, Lianghui,Lian, Ruochun, 4 Zhang, Xu,Hu, Lina(*),Zeng, Yong(*),Association of peripheral blood dendritic cells with recurrent pregnancy loss: a case-controlled study.,Am J Reprod Immunol,2016.10.01,76 (4):326~332

  (10) Liang, Pei-Yan(#),Diao, Liang-Hui,Huang, Chun-Yu ,Lian, Ruo-Chun,Chen, Xian,Li, Guan-Gui,Zhao, Jin,Li, Yu-Ye,He, Xue-Bing,Zeng, Yong(*),The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure.,Reprod Biomed Online,2015.12.01,31(6):823~826

  編著

  Diao, Lianghui; Cai, Songchen; Ding, Jinli; Zeng, Yong; Metabolic and Nutritional Impact on Endometrial Gene Expression and Reproductive Disorder, Endometrial Gene Expression,2020, (199-214)

  大會報告(大會口頭報告)

  (1)Lianghui Diao; The Immunometabolism of early pregnancy - evidence from dendritic cells and regulatory T cells, 第一屆(2019)母胎醫學科學研究大會(廈門), 廈門大學, 2019-12-6 至 2019-12-9. (大會報告)

  (2)Lianghui Diao; Maria Emilia Solano; Yong Zeng; Kristin Thiele; Petra Arck; The immune metabolic adaptations during early pregnancy: lessons learned from tumor immunology, The 38th Annual Meeting of the American Society for Reproductive Immunology, 上海, 2018-6-28 至 2018-7-1. (大會報告)

  授權專利

  (1)曾勇; 刁梁輝; 黃春宇; 李玉葉; 連若純; 一種子宮血管阻斷鉗, 2020-3-31, 中國, ZL 2019 2 0201722. 1. (發明專利)

  (2)黃春宇; 刁梁輝; 陳現; 李玉葉; 連若純; 陳聰; 一種用於評估子宮內膜容受性的試劑盒及其使用方法, 2017-10-31, 中國, ZL 2016 1 0021908. X. (發明專利)