黃春宇
黃春宇

姓名:黃春宇
職稱/頭銜:博士 院長助理
所屬科室:生殖科
從業年限:
技術專長:種植窗期免疫細胞對胚胎的耐受機制、複發性流產和反覆種植失敗患者的子宮內膜免疫細胞評估體系的建立

個人簡介

  香港大學博士。錦欣醫療科技創新中心副主任,深圳中山泌尿外科醫院院長助理。擅長領域:NK細胞及γδ-T細胞在生殖障礙疾病中的作用機制研究;醫學統計學及人工智能技術(AI)在生殖臨床輔助決策中的應用探索研究。社會任職:美國生殖免疫協會(ASRM)委員,中國免疫學會會員,廣東省免疫協會生殖免疫專業委員會委員,《Journal of Reproductive Immunology》和 《American Journal of Reproductive Immunology》審稿專家。

  業務領域:

  主要研究方向為種植窗期免疫細胞對胚胎的耐受機制,以及複發性流產和反覆種植失敗患者的子宮內膜免疫細胞評估體系的建立。

  學術成果:

  主持或參加科研項目(課題)及人才計劃項目情況(按時間倒序排序):

  1、 深圳市衛計委學科建設能力提升項目、SZXJ2018004、子宮內膜自然殺傷細胞對反覆胚胎種植失敗患者妊娠結局的預測價值及臨床應應用、2018/05-2021/05、10 萬、在研、主持;

  2、 中華醫學會生殖醫學青年醫師研究與發展項目、18010110740、HCG 日高水平孕酮影響子宮 NK 細胞功能的分子機制研究、2019/06-2021/06、13 萬、在研、主持;

  3、 國自然青年科學基金項目、81701529、HIF-1α 與雌激素協同調控 Tregs 功能和子宮 2 內膜微環境的機制研究、2018/01-2020/12,20 萬,在研、參與(第二);

  4、 深圳市科創委基礎研究計劃、JCYJ20150402165325178、uNK 通過毒性顆粒影響 RIF 患者妊娠結局的分子機制研究、2015/08-2017/08、15 萬元、已結題、參與(第二);

  5、 深圳市科創委基礎研究計劃、JCYJ20120829150019348、反覆胚胎種植失敗中樹突狀細胞對免疫耐受和血管新生的影響、2013/06-2016/06、20 萬元、已結題、參與(第三)。

  代表性研究成果和學術獎勵

  一、期刊論文

  1. 第一作者或通訊作者論文

  (1) Chunyu Huang, Yong Zeng, Wenwei Tu* , Single-cell RNA Sequencing Deciphers Immune Landscape of Human Recurrent Miscarriage. Genomics, Proteomics & Bioinformatics, Accept.

  (2) Chunyu Huang, Yongnu Zhang, Zheng Xiang, Yuye Li, Rong Lin, Jian Xu, Wenwei Tu, Yong Zeng, Granzyme B-expressing γδ-T and NK cells as a predictor of clinical pregnancy failure in patients with unexplained implantation failure. Journal of Reproductive Immunology. DOI: 10.1016/j.jri.2020.103269.

  (3) Yongnu Zhang† , Chunyu Huang† , Ruochun Lian, Jian Xu, Yunfeng Fu, Yong Zeng*, Wenwei Tu*, The low cytotoxic activity of peripheral blood NK cells may relate to unexplained recurrent miscarriage. American Journal of Reproductive Immunology. DOI: 10.1111/aji.13388

  (4) Chunyu Huang, Yong Zeng*, Wenwei TU*, The role of gdT cells during human pregnancy. American Journal of Reproductive Immunology. 2017, 78 (2), DOI: 10.1111/aji.12713.

  (5) Chunyu Huang† , Hongzhan Zhang† , Xian Chen, Lianghui Diao, Ruochun Lian, Xu Zhang, Lina Hu* , Yong Zeng* . Association of peripheral blood dendritic cells with recurrent pregnancy loss: a case-controlled study. American Journal of Reproductive Immunology. 2016, 76(4), 326-332. (共第一作者) 3

  (6) Chunyu Huang, Peiyan Liang, Lianghui Diao, Cuicui Liu, Xian Chen, Guangui Li, Cong Chen and Yong Zeng* . Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure. Int. J. Environ. Res. Public Health 2015, 12, 10352-10361.

  (7) Jinli Wang# , Chunyu Huang# , Minhao Wu, Qiu Zhong, Kun Yang, Miao Li, Xiaoxia Zhan, Jinsheng Wen, Lin Zhou*, Xi Huang*. MRP8/14 induces autophagy to eliminate intracellular Mycobacterium bovis BCG. J Infect, 2015, 70 (4), 415-426. (共第一作者)

  2. 既非第一作者又非通訊作者論文

  (1) Linlin Wang# , Longfei Li# , Chunyu Huang, Lianghui Diao, Ruochun Lian, Yuye Li, Shan Xiao, Xiuyu Hu, Meilan Mo and Yong Zeng. Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro fertilization treatment. Fertility and Sterility,2019.

  (2) Hongxia Wei, Su Liu, Ruochun Lian, Chunyu Huang, Yuye Li, Lanna Chen, Yong Zeng*. Abnormal expression of indoleamine 2, 3-dioxygenase in human recurrent miscarriage. Reproductive Sciences,2019.

  (3) Yuye Li# , Shuyi Yu# , Chunyu Huang, Ruochun Lian, Cong Cheng, Su Liu, Longfei Li, Lianghui Diao, Udo R. Markert, Yong Zeng. Evaluation of Peripheral and Uterine Immune Status of Chronic Endometritis in Recurrent Reproductive Failure Patients. Fertility and sterility,2019

  (4) Longfei Li# , Linlin Wang# , Chunyu Huang, Lianghui Diao, Yongnu Zhang, Xu Zhang, Jian Xu, Yong Zeng* . Chronic Hepatitis B Infections Altered Peripheral Immune Response in Women with Reproductive Failure. American journal of reproductive immunology. 2018

  (5) Su Liu, Hongxia Wei, Yuye Li, Chunyu Huang, Ruochun Lian, Jian Xu, Lanna Chen, Yong Zeng*. Downregulation of ILT4+ dendritic cells in recurrent miscarriage and 4 recurrent implantation failure. American Journal of Reproductive Immunology. 2018, 80 (4), e12998

  (6) Tao Zhang, Chunyu Huang, Yan Du, Ruochun Lian, Meilan Mo, Yong Zeng* and Gil Mor. Successful treatment with intrauterine delivery of dexamethasone for repeated implantation failure. American Journal of Reproductive Immunology. 2017, 78(6), e12766

  (7) Su Liu, Lianghui Diao, Chunyu Huang, Yuye Li, Yong Zeng* and Joanne Kwak-Kim. The role of decidual immune cells on human pregnancy. Journal of Reproductive Immunology. 124 (2017) 44-53

  (8) Xian Chen, Meilan Mo, Chunyu Huang, Lianghui Diao, Guangui Li, Yuye Li, Aaron Lerner, Yehuda Shoenfeld, Yong Zeng*. Association of serum autoantibodies with pregnancy outcome of patients undergoing first IVF/ICSI treatment: A prospective cohort study. Journal of Reproductive Immunology. 122 (2017) 14-20

  (9) Jin-Li Ding# , Lianghui Diao# , Tai-lang Yin, Chunyu Huang, Biao Yin, Cong Chen, YI ZHANG, Jie Li, Yan-Xiang Cheng, Yong Zeng, Jing Yang. Aberrant expressions of endometrial Id3 and CTLA-4 are associated with unexplained repeated implantation failure and recurrent miscarriage. American Journal of Reproductive Immunology. DOI:10.1111/aji.12632.

  (10) Liang-Hui Diao, Guan-Gui Li, Yuanchang Zhu, Wenwei Tu, Chunyu Huang, Ruo-Chun Lian, Xian Chen, Yuye Li, Tao Zhang, Yong Huang, Yong Zeng. Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells. American Journal of Reproductive Immunology. 2017, 77(3)

  (11) PeiYan Liang, LiangHui Diao, ChunYu Huang, RuoChun Lian, Xian Chen, GuanGui Li, Jin Zhao, YuYe Li, XueBing He, Yong Zeng. The pro-inflammatory and anti-inflammatory cytokine profile in women with recurrent implantation failure. Reproductive BioMedicine Online, 2015, 31(6):823-826

  大會報告(大會口頭報告)

  (1) Chunyu Huang, Reproductive Failure: Immune or autoimmune abnormality from male and female. The 8th Congress of the International Society for Gender Medicine, 2017, Japan. (Invited Speaker) 2017, 9.14-17

  (2) Chunyu Huang, The prevalence and associated factors of autoantibodies in reproductive failure. First Interdisciplinary Scientific Conference on Autoimmune and Immunodeficiency Diseases, Moscow, Russian, 08-10 December, 2016.

  (3) Chunyu Huang, The prevalence of anti-phospholipid antibodies, anti-thyroid antibodies and anti-nuclear antibodies in patients experiencing infertility, repeated implantation failure and recurrent miscarriage. The 10th International Congress on Autoimmunity, Leipzig, Germany, 06-10 April, 2016.

  (4) 黃春宇,NK 細胞數量和功能檢測在生殖失敗患者中的臨床應用,廣東省免疫學會生殖免疫學專業委員會2016年學術年會,中國,廣州,2016年12月17-18 日

  (5) 黃春宇,周圍血樹突狀細胞與複發性流產的相關性研究:病例對照研究,廣東省免疫學會 2016年學術年會,中國,廣州,2016年9月10日

  (6) 黃春宇,反覆種植失敗患者DC細胞數量和功能分析,2015年中國生殖免疫學會年會暨2015 年重慶市免疫學會年會,中國,重慶,2015年9月

  授權專利

  (1) 黃春宇; 刁梁輝; 陳現; 李玉葉; 連若純; 陳聰; 一種用於評估子宮內膜容受性的試劑盒及其使用方法, 2017-10-31, 中國, ZL 2016 1 0021908. X. (發明專利)

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