劉蘇
劉蘇

姓名:劉蘇
職稱/頭銜:博士
所屬科室:生殖科
從業年限:
技術專長:種植窗期免疫細胞對胚胎的耐受機制、樹突狀細胞在複發性流產和反覆種植失敗中的調控機制

個人簡介

  新加坡國立大學博士,深圳中山泌尿外科醫院生殖醫學臨床研究中心高級工程師,錦欣醫療科技創新中心 PI,深圳市海外高層次人才。擅長領域:多囊卵巢綜合征的病理機制、子宮內膜免疫微環境及相關診療策略。

  業務領域:

  主要從事種植窗期免疫細胞對胚胎的耐受機制,以及樹突狀細胞在複發性流產和反覆種植失敗中的調控機制及相關診療策略的研究,並將基礎研究技術應用於解決臨床問題,旨在從臨床免疫學角度提高輔助生殖率。

  學術成果:

  主持或參加科研項目(課題)及人才計劃項目情況(按時間倒序排序):

  1. 國家自然科學基金委員會,青年項目,82001547,孕酮通過調控樹突狀細胞脂肪酸代謝參與母胎免疫耐受的分子機制,2021/01-2023/12,24 萬元,在研,主持。

  2. 深圳市自然科學基金面上項目,JCYJ20190813160809117,孕酮參與母胎界面樹突狀細胞免疫代謝調控的分子機制,2020/10-2023/09,10 萬,在研,主持。

  3. 廣東省自然科學基金項目,2019A15150109,孕酮參與母胎界面 DC 代謝重塑和功能調控的分子機制,2019/10-2022/09,10 萬,在研,主持。

  4. 深圳市衛生和計劃生育委員會博士創新項目,SZBC2018003,IDO 在複發性流產中的作用及分子機制,2018/05-2021/05,10 萬,在研,主持。

  5. 中華醫學會臨床醫學科研專項資金項目,17020300699,子宮內膜樹突狀細胞影響反覆種植失敗患者妊娠結局的分子機制研究,2018/01-2019/12,15 萬,結題,主持。

  6. 深圳市科技創新委員會基礎研究項目,JCYJ20170307140647669,子宮內膜 DC 通過 ILT4/HLA-G 通路影響反覆種植失敗的分子機制研究,2017/05-2020/05, 10 萬,在研,主持。

  代表性研究成果和學術獎勵

  一、期刊論文

  1. 第一作者或通訊作者論文

  (1) Su Liu, Meilan Mo, Shan Xiao, Longfei Li, Xiuyu Hu, Ling Hong, Linlin Wang, Ruochun Lian, Chunyu Huang, Yong Zeng and Lianghui Diao*. Pregnancy Outcomes of Women With Polycystic Ovary Syndrome for the First In Vitro Fertilization Treatment: A Retrospective Cohort Study With 7678 Patients. Front Endocrinol, 2020. 11:575337. doi: 10.3389/fendo.2020.575337.

  (2) Su Liu, Ling Hong, Yuye Li, Ruochun Lian, Xiaohui Wang and Yong Zeng*. Association between endometrial indoleamine 2,3-dioxygenase expression level and pregnancy outcomes in women undergoing first in vitro fertilization treatment. BMC Pregnancy and Childbirth 21, 33 (2021). https://doi.org/10.1186/s12884-020-03511-9.

  (3) Liu Su# , Xu Fen# , Wei Hongxia, Huang Chunyu, Chen Xian, Lian Ruochun, Zeng Yong*. The correlation of thyroid autoimmunity and peripheral and uterine immune status in women with recurrent miscarriage. J Reprod Immunol, 2020. 139:103118.

  (4) Liu Su# , Wei Hongxia# , Li Yuye, Diao Lianghui, Lian Ruochun, Zhang Xu, Zeng Yong*. Characterization of dendritic cell (DC)-10 in recurrent miscarriage and recurrent implantation failure. Reproduction, 2019. 158(3): 247-255.

  (5) Hongxia Wei# , Su Liu# , Ruochun Lian, Chunyu Huang, Yuye Li, Lanna Chen, Yong Zeng*. Abnormal expression of indoleamine 2,3-dioxygenase in human recurrent miscarriage. Reproductive Sciences, 2019. 27(8), 1656-1664. DOI: 10.1177/1933719119833788.

  (6) Su Liu, Hongxia Wei, Yuye Li, Chunyu Huang, Ruochun Lian, Jian Xu, Lanna Chen, Yong Zeng*. Downregulation of ILT4(+) dendritic cells in recurrent miscarriage and recurrent implantation failure. Am J Reprod Immunol, 2018. 80(4): p. e12998.

  (7) Su Liu, Lianghui Diao, Chunyu Huang, Yuye Li, Yong Zeng*, Joanne Y.H. Kwak-Kim*. The role of decidual immune cells on human pregnancy. J Reprod Immunol, 2017. 124: p. 44-53.

  (8) Lian Ruochun, Wang Xiaohui, Lin Rong, Zeng Huimin, Zeng Yong, Liu Su*. Evaluation of granulocyte colony-stimulating factor on the treatment of thin endometrium during frozen-thawed embryo transfer cycles: a retrospective cohort study. Gynecol Endocrinol, 2020. 36(4): 370-374.

  (9) Liu Su# , Yuan Zuanning# , Yuan Yu-Ren Adam*. Structural insights into specific crRNA G-rich sequence binding by Meiothermus ruber Cse2. J Struct Biol, 2015. 190(2):122-34.

  (10) 徐士儒,劉蘇*,李玉葉,陳聰,林嘉音,曾勇,不明原因複發性自然流產患者分泌期子宮內膜樹突狀細胞數量分析. 中華生殖與避孕,2018. 38 (2): p.89-95.

  2. 既非第一作者又非通訊作者論文

  (1) Xian Chen, Lianghui Diao, Ruochun Lian, Lingbin Qi, Shuyi Yu, Su Liu, Shenglai Lin, Zhigang Xue, Yong Zeng* . Potential impact of maternal vitamin D status on peripheral blood and endometrium cellular immunity in women with recurrent implantation failure. Am J Reprod Immunol, 2020. DOI: https://doi.org/10.1111/aji.13243.

  (2) Zhang, H., C. Huang, X. Chen, L. Li, S. Liu, Y. Li, Y. Zhang, Y. Zeng, and L. Hu, The number and cytotoxicity and the expression of cytotoxicity-related molecules in peripheral natural killer (NK) cells do not predict the repeated implantation failure (RIF) for the in vitro fertilization patients. Genes Dis, 2020. 7(2): p. 283-289.

  (3) Li Yuye# , Yu Shuyi# , Huang Chunyu, Lian Ruochun, Chen Cong, Liu Su, Li Longfei, Diao Lianghui, Udo Markert, Zeng Yong* . Evaluation of peripheral and uterine immune status of chronic endometritis in patients with recurrent reproductive failure. Fertil Steril, 2020. 113(1): 187-196 e181.

  (4) Lianghui Diao, Songchen Cai, Chunyu Huang, Longfei Li, Shuyi Yu, Linlin Wang, Su Liu, Yuye Li* , YongZeng* . New endometrial immune cell-based score (EI-score) for the prediction of implantation success for patients undergoing IVF/ICSI. Placenta, 2020. 99, 180-188.

  (5) Xian Chen, Su Liu, Qiao Tan, Yehuda Shoenfeld* , Yong Zeng* . Microbiome, autoimmunity, allergy, and helminth infection: the importance of the pregnancy period. Am J Reprod Immunol, 2017. 78(2):p. e12654.

  (6) Biao Yin, Yong Zeng, Tonghua Wu, Shuyi Yu, Jian Xu, Su Liu, Lianghui Diao, Zhenfu Zhao, Desheng Liang* , Yuye Li* . Functional properties of peripheral CD8(+) T cells in patients with repeated implantation failure. Am J Reprod Immunol, 2017. 78(2):p. e12654.

  (7) Tay Melanie, Liu Su, Yuan Yu-Ren Adam*. Crystal structure of Thermobifida fusca Cse1 reveals target DNA binding site. Protein Sci, 2014. 24(2):236-45.

  二、會議論文

  (1) 2019 年 6 月 12 日,美國,大急流城,美國生殖免疫年會,大會牆報,題目: Progesterone regulates dendritic cell function and metabolism during pregnancy.

  (2) 2018 年 8 月 29 日,丹麥,奧爾堡,歐洲生殖免疫年會,口頭彙報,題目:Impaired peripheral blood HLA-G+ T cells are associated with recurrent miscarriage and recurrent implantation failure.

  (3) 2018 年 6 月 28 日,中國,上海,美國生殖免疫年會,口頭彙報,題目: The role of dendritic cells in human pregnancy.

  (4) 2017 年 9 月 17 日,美國,芝加哥,美國生殖免疫年會,大會牆報,題目:Detailed analysis of natural killer cell cytotoxicity and Th1-related cytokines before and after lymphocyte immunotherapy in patients with unexplained recurrent miscarriage.

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