李玉葉
李玉葉

姓名:李玉葉
職稱/頭銜:博士 檢驗中心主任
所屬科室:生殖科
從業年限:
技術專長:子宮內膜容受性的分子機制及免疫細胞及分子在複發性流產患者和反覆種植患者的發病機制和臨床應用

個人簡介

  中山大學免疫學博士。深圳中山泌尿外科醫院檢驗中心主任,錦欣醫療科技創新中心副主任。擅長領域:慢性子宮內膜炎診斷標準與致病機制、子宮內膜免疫微環境預測指標及臨床干預策略。社會任職:中國免疫學會生殖免疫分會第五屆委員會委員、婦幼健康研究會生殖免疫學專業委員會委員、美國生殖免疫協會會員。

  學術成果:

  主持或參加科研項目(課題)及人才計劃項目情況(按時間倒序排序):

  1、 深圳市自然科學基金、JCYJ20190803142103857、早孕期滋養細胞通過IDO-AhR誘導蛻膜CD8+T細胞PD-1表達的機制研究、2020/08-2023/08,10萬,在研,主持。

  2、 國家自然科學基金青年項目、81601279、子宮內膜CD8+T細胞通過Fas通路促進滋養細胞侵襲的分子機制研究,2017/01-2019/12,17.5萬,主持,結題。

  3、中華醫學會臨床醫學科研專項資金、16020200636、子宮內膜CD8+T細胞對滋養層細胞調控機制的研究,2017/01-201912,11萬,主持,結題。

  代表性研究成果和學術獎勵

  一、期刊論文

  1. 第一作者或通訊作者論文

  (1)Li Yuye # ,Xu Shiru# , Yu Shuyi, Huang Chunyu, Lin Shenglai, Chen Wanru, Mo Meilan, Lian Ruochun, Diao Lianghui, Ding Lijun *, Zeng Yong *, Diagnosis of chronic endometritis: 2 How many CD138 + cells/HPF in endometrial stroma affect pregnancy outcome of infertile women? doi:10.1111 /aji.13369.(第一作者)

  (2) Diao, Lianghui(#), Songchen Cai(#), Chunyu Huang, Longfei Li, Shuyi Yu, Linlin Wang, Su Liu, Yuye Li(*), and Yong Zeng(*). New Endometrial Immune Cell-Based Score (Ei-Score) for the Prediction of Implantation Success for Patients Undergoing IVF/ICSI, Placenta (2020) 99, 180-188. (通訊作者)

  (3) Li Yuye(#), Yu Shuyi(#), Huang Chunyu, Lian Rruochun, Chen Cong, Liu Su, Li Longfei, Diao Lianghui, Udo R Markert(*), Zeng Yong(*). Evaluation of peripheral and uterine immune status of chronic endometritis in patients with recurrent reproductive failure. Fertil Steril 2019. (第一作者)

  (4) Yin Biao(#), Zeng Yong, Wu Tonghua, Yu Shuyi, Xu Jian, Liu Su, Diao Lianghui, Zhao Zhengfu, Desheng Liang(*), Li Yuye(*). Functional properties of peripheral CD8(+) T cells in patients with repeated implantation failure. Am J Reprod Immunol 2017;78.(通訊作者)

  (5) Li Yuye(#), Wu Siyu, Pu Jieying, et al. Dengue Virus Upregulates Expression of Notch Ligands Dll1 and Dll4 Through IFN- β Signaling Pathway. Immunology, 2015 Jan;144(1):127-38. (第一作者) (6) Zhang Peifen(#), Li Yuye(#), Xia Jiong, He Junfang, Pu Jieying, Xie Jiong et al. IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation. J Cell Sci 2014;127:2471-82.(第一作者)

  (7) Li Yuye(#), Xie Jiong, Wu Siyu, et al. Protein kinase regulated by dsRNA downregulates the interferon production in dengue virus- and dsRNA-stimulated human lung epithelial cells. PLoS One 2013;8:e55108.(第一作者)

  2. 既非第一作者又非通訊作者論文

  (1) Liu S, Wei H, Li Y, Diao L, Lian R, Zhang X et al. Characterization of Dendritic Cell(DC)10 in recurrent miscarriage and recurrent implantation failure. Reproduction 2019.

  (2) Wei H, Liu S, Lian R, Huang C, Li Y, Chen L et al. Abnormal Expression of Indoleamine 2, 3-Dioxygenase in Human Recurrent Miscarriage. Reprod Sci 2019:1933719119833788.

  (3) Wang L, Li L, Huang C, Diao L, Lian R, Li Y et al. Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro 3 fertilization treatment. Fertil Steril 2019;112:250-7 e1.

  (4) Liu S, Wei H, Li Y, Huang C, Lian R, Xu J et al. Downregulation of ILT4(+) dendritic cells in recurrent miscarriage and recurrent implantation failure. Am J Reprod Immunol 2018;80:e12998.

  (5) Liu S, Diao L, Huang C, Li Y, Zeng Y, Kwak-Kim JYH. The role of decidual immune cells on human pregnancy. J Reprod Immunol 2017;124:44-53.

  (6) Pu J, Wu S, Xie H, Li Y, Yang Z, Wu X et al. miR-146a Inhibits dengue-virus-induced autophagy by targeting TRAF6. Arch Virol 2017;162:3645-59.

  (7) Pu J, He L, Xie H, Wu S, Li Y, Zhang P et al. Antiviral activity of Carbenoxolone disodium against dengue virus infection. J Med Virol 2017;89:571-81.

  (8) Xia J, Chen X, Xu F, Wang Y, Shi Y, Li Y et al. Dengue virus infection induces formation of G3BP1 granules in human lung epithelial cells. Arch Virol 2015;160:2991-9.

  (9) Wu S, He L, Li Y, Wang T, Feng L, Jiang L et al. miR-146a facilitates replication of dengue virus by dampening interferon induction by targeting TRAF6. J Infect 2013;67:329-41.

  二、學術獎勵

  “原因複發性流產患者免疫狀態評估體系的建立” 深圳市科技進步獎 一等獎

  三、大會報告(大會口頭報告)

  Li Yuye, Endometrial CD8+T cells testing in women with repeated implantation failure, The 38th Annual Meeting of the American Society for Reproductive Immunology, 上海, 2018-6-28 至 2018-7-1. (大會報告,並獲得“John Gusdon Award”最佳口頭報告獎。)

  四、授權專利

  (1)曾勇; 刁梁輝; 黃春宇; 李玉葉; 連若純; 一種子宮血管阻斷鉗, 2020-3-31, 中國, ZL 2019 2 0201722. 1. (發明專利)

  (2)黃春宇; 刁梁輝; 陳現; 李玉葉; 連若純; 陳聰; 一種用於評估子宮內膜容受性的試劑盒及其使用方法, 2017-10-31, 中國, ZL 2016 1 0021908. X. (發明專利)

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