李龍飛
李龍飛

姓名:李龍飛
職稱/頭銜:博士 檢驗中心副主任
所屬科室:檢驗中心
從業年限:
技術專長:複發性流產及反覆種植失敗的免疫診療新策略

個人簡介

  香港中文大學博士&博士后。深圳中山泌尿外科醫院檢驗中心副主任,錦欣醫療科技創新中心PI,深圳市海外高層次人才。擅長領域:感染、代謝與妊娠併發症;內膜容受性標誌物的開發與應用;社會任職:Current Medicinal Chemistry,International Journal of Molecular Medicine,Phytomedicine,Molecules, Cellular and Molecular Biology等雜誌的特邀審稿人。

  研究方向:

  感染、代謝與妊娠併發症;內膜容受性標誌物的開發與應用;幹細胞研究與開發。

  學術成果:

  主持或參加科研項目(課題)及人才計劃項目情況(按時間倒序排序):

  1. 國家自然科學基金,“TCP-2 腫瘤靶向肽在結腸組織上特異性靶標的分離鑒定及靶向傳輸免疫治療藥物的研究”,2017.01-2019.12,17.3 萬元,負責人,已結題;

  2. 廣東省自然科學基金面上項目,“IGF-1 通過上調子宮基質細胞丙酮酸激酶的表達促進蛻膜化的機制研究”,2019.10-2022.09,10 萬元,負責人,在研;

  3. 深圳市自然科學基金面上項目,“滋養層細胞與母胎界面巨噬細胞極化的相互作用及機制研究”,2020-2023,20 萬元,負責人,在研;

  4. 香港研究資助局優配研究基金,2140836,“腫瘤血管靶向肽(TCP-1 多肽)結合位點的分離及靶向治療結腸癌的研究”,2014/01-2015/12,港幣 64.9 萬元,已結題,主要完成人;

  5. 香港中文大學知識產權轉移項目,TBF14MED010, “結腸癌及其他消化道腫瘤診療的新製劑的研發”; 2014.1-2015.7, 港幣 20 萬元,已結題,主要完成人;

  6. 香港創新科技署第三層撥款項目及種子項目,6903572,“基於 TCP-1 多肽靶向傳輸 TNF α 和 IFN γ 治療結腸癌的研究”,2013.9-2015.5, 港幣 146 萬,已結題,參加;

  7. 中國科學院昆明植物研究所,開放課題項目,P2009-KF03,“玉紅牛肝菌中抗癌活性成分的研究”,2009.1-2010.12,人民幣 10 萬元,已結題,主要完成人。 8. 深圳市海外高層次人才 C 類,2018.06-2023.06.

  代表性研究成果和學術獎勵

  一、期刊論文

  1. 第一作者或通訊作者論文

  1.1 .馬靜文,王琳琳,張燕,武婭婭,陳聰,吳娟花,連若純,楊菁*,李龍飛﹡. 早孕期蛻膜免疫細胞譜及與妊娠的相關性。生殖醫學雜誌,2021(已接收)。

  1.2 .Li, L.F., G.G.L. Yue, B.C.L. Chan, Q. Zeng, Q.B. Han, P.C. Leung, K.P. Fung, J.K. Liu, and C.B.S. Lau, Rubinoboletus ballouii polysaccharides exhibited immunostimulatory activities through toll‐ like receptor‐4 via NF‐κB pathway. Phytotherapy Research, 2020.

  1.3.Wang, L.#, L. Li#(共同一作), C. Huang, L. Diao, R. Lian, Y. Li, S. Xiao, X. Hu, M. Mo, and Y. Zeng, Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro fertilization treatment. Fertil Steril, 2019. 112(2): p. 250-257 e1.

  1.4.Longfei Li(第一作者), Linlin Wang, Chunyu Huang, Lianghui Diao, Yongnu Zhang, Xu Zhang, Jian Xu and Yong Zeng. Chronic hepatitis B infection alters peripheral immune response in women with reproductive failure. American Journal of Reproductive Immunology. 2019, 81(3): e13083.

  1.5.肖小龍,莫觀,廉雲,劉運蕾,李龍飛(通訊作者). 大分子靈芝多糖對非小細胞肺癌細胞增殖、遷移和侵襲能力的抑制作用。上海中醫藥大學學報,2018,32(6):56-60。

  1.6. Li, L.F.*(第一作者和通訊作者), Chan, R.L., Lu, L., Shen, J., Zhang, L., Wu, W.K., et al., Cigarette smoking and gastrointestinal diseases: The causal relationship and underlying molecular mechanisms, International Journal of Molecular Medicine. 34 (2014), 372-80.

  1.7.Li, L.F.(第一作者), Chan, B.C., Yue, G.G., Lau, C.B., Han, Q.B., Leung, P.C., et al., Two immunosuppressive compounds from the mushroom Rubinoboletus ballouii using human peripheral blood mononuclear cells by bioactivity-guided fractionation, Phytomedicine. 20 (2013), 3 1196-202.

  2. 既非第一作者又非通訊作者論文

  2.1.Li, Y., S. Yu, C. Huang, R. Lian, C. Chen, S. Liu, L. Li, L. Diao, U.R. Markert, and Y. Zeng, Evaluation of peripheral and uterine immune status of chronic endometritis in patients with recurrent reproductive failure. Fertil Steril, 2020. 113(1): p. 187-196 e1.

  2.2 .Zhang, H., C. Huang, X. Chen, L. Li, S. Liu, Y. Li, Y. Zhang, Y. Zeng, and L. Hu, The number and cytotoxicity and the expression of cytotoxicity-related molecules in peripheral natural killer (NK) cells do not predict the repeated implantation failure (RIF) for the in vitro fertilization patients. Genes Dis, 2020. 7(2): p. 283-289.

  2.3. Zeng, Q., L. Li, Y. Jin, Z. Chen, L. Duan, M. Cao, M. Ma, and Z. Wu, A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Paeonia lactiflora Pall. On the Treatment of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine, 2019: p. 8706589.

  2.4. Zeng, Q., L. Li, W. Siu, Y. Jin, M. Cao, W. Li, J. Chen, W. Cong, M. Ma, K. Chen, and Z. Wu, A combined molecular biology and network pharmacology approach to investigate the multi-target mechanisms of Chaihu Shugan San on Alzheimer's disease. Biomed Pharmacother, 2019. 120: p. 109370.

  2.5. Zhang, L., W. Hu, C.H. Cho, F.K. Chan, J. Yu, J.R. Fitzgerald, C.K. Cheung, Z.G. Xiao, J. Shen, L.F. Li, M.X. Li, J.C. Wu, T.K. Ling, J.Y. Chan, H. Ko, G. Tse, S.C. Ng, S. Yu, M.H. Wang, T. Gin, H. Ashktorab, D.T. Smoot, S.H. Wong, M.T. Chan, and W.K. Wu, Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. J Pathol, 2018. 244(4): p. 432-444.

  2.6. Li, M.X., Li, L.F., Zhang, L., Xiao, Z.G., Shen, J., Hu, W. & Cho, C.H. (2016). Vitamin D and cancer stem cells in the gastrointestinal tract. Curr. Med. Chem. 2017;24(9):918-927. (invited).

  2.7. Li, M.X., Li, L.F., Zhang, L., Hu, W., Shen, J., Xiao, Z.G., Chan, F.L., Cho, C.H. (2017). 1,25-Dihydroxyvitamin D3 suppresses cancer growth through VDR and mutant p53 in the induction of p21 expression in gastric cancer. Life Sciences 179 (2017) 88–97.

  2.8. Wong CC, Zhang L, Wu WK, Shen J, Chan RL, Lu L, Hu W, Li MX, Li LF, Ren SX, Li YF, Li J, Cho CH. Cathelicidin-encoding Lactococcus lactis promotes mucosal repair in murine experimental colitis. J Gastroenterol Hepatol. 2017;32(3):609-619.

  2.9. Zeng Q, Ko CH, Siu WS, Li LF, Han XQ, Yang L, Bik-San Lau C, Hu JM, Leung PC. Polysaccharides of Dendrobium officinale Kimura & Migo protect gastric mucosal cell against oxidative damage-induced apoptosis in vitro and in vivo. J Ethnopharmacol. 2017 Jul 4;208:214-224. 4

  2.10. Shen J, Li ZJ, Li LF, Lu L, Xiao ZG, Wu WK, Zhang L, Li MX, Hu W, Chan KM, Cho CH. (2016). Vascular-targeted TNFα and IFNγ inhibit orthotopic colorectal tumor growth. J. Translat. Med. 2016 24;14(1):187.

  2.11.Xiao ZG, Shen J, Zhang L, Li LF, Li MX, Hu W, Li ZJ, Cho CH. The Roles of Histone Demethylase UTX and JMJD3 (KDM6B) in Cancers: Current Progress and Future Perspectives. Curr Med Chem. 2016;23(32):3687-3696.

  2.12. Shen J, Li WX, Xiao ZG, Zhang L, Li MX, Li LF, Hu W, Lu L, Boudreau F, Cho CH. The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. Curr Med Chem. 2016; 23(11):1131-8.

  2.13.Wang L, Hu T, Shen J, Zhang L, Li LF, Chan RL, Li MX, Wu WKK, Cho CH. (2016). Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. Life Sci, pii: S0024-3205(16)30134-5.

  2.14.Xu Z, Shen J, Wang MH, Yi T, Yu Y, Zhu Y, Chen B, Chen J, Li L, Li M, Zuo J, Jiang H, Zhou D, Luan J, Xiao Z. Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer. Oncoimmunology. 2016 Jul 11;5(8):e1207841.

  2.15.L. Lu, Z.J. Li, L.F. Li, W.K. Wu, J. Shen, L. Zhang, R.L. Chan, L. Yu, Y.W. Liu, S.X. Ren, K.M. Chan, C.H. Cho, Vascular-targeted TNFalpha improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer, J Control Release, 210 (2015) 134-46.

  2.16.Chan, B.C.L., Li, L.F., Hu, S.Q., Wat, E., Wong, E.C.W., et al. Gallic Acid Is the Major Active Component of Cortex Moutan in Inhibiting Immune Maturation of Human Monocyte-Derived Dendritic Cells. Molecules. 20 (2015), 16388-403.

  2.17.Hu, T., Li, L.F. & Cho, C.H. Chronic inflammation and colorectal cancer: the role of vascular endothelial growth factor. Curr. Pharmaceut. Design. 21 (2015), 2960-7.

  2.18.Luo KW, Yue GG, Ko CH, Lee JK, Gao S, Li LF, Li G, Fung KP, Leung PC, Lau CB, In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma. Phytomedicine. 21 (2014), 1078-87.

  二、會議論文

  1. Longfei Li, Linlin Wang, Lianghui Diao, Chunyu Huang, Yong Zeng. Maternal Hepatitis B Virus Infection Modulated Immune Cells Profiles in Endometrium from Women with Reproductive Failure. International Society for Immunology of Reproduction. Nov. 13-16, 2019, Nara Japan.

  2. Longfei Li, Linlin Wang, Chunyu Huang, Juanhua Wu, Yaya Wu and Yong Zeng. Immune profiles in the endometrium during implantation window and in the decidua of early pregnancy. Journal of Reproductive Immunology. 2018, 128: 57.

  3. Longfei Li, Linlin Wang, Yuanchang Zhu, Cong Chen, Juanhua Wu and Yong Zeng. Human placental Hofbauer cells are markedly decreased in spontaneous miscarriage. American Journal of Reproductive Immunology. 2018, 80 S1 P13.

  4. Linlin Wang, Longfei Li, Juanhua Wu, Cong Chen and Yong Zeng. Higher macrophages infiltration is correlated with poor outcome in early pregnancy. American Journal of Reproductive Immunology. 2018, 80 S1 P27.

  5. Long Fei Li, Lan Lu, Zhi Jie Li, Chi Hin Cho, “Can TCP-1, a peptide targeting colon cancer reduce the side effects of TNF-alpha?” Poster presentation in “Pan Pacific Symposium on Stem Cells and Cancer Research”, April 12-14, 2014, Taiwan. (Received Best Poster Presentation Award)

  6. Li LF, Yue GGL, Chen BCL, Lau CBS, Han QB, Liu JK, Leung PC and Fung KP, “In vitro investigations on the immunomodulatory activities of Rubinoboletus ballouii using human peripheral blood mononuclear cells.” Poster presentation in “6th International Functional Food Symposium”, October 25-26, 2012, Hong Kong. (Received Best Poster Presentation Award)

  7. Li LF, Yue GGL, Chen BCL, Lau CBS, Han QB, Liu JK, Leung PC and Fung KP, “Investigations on the immunomodulatory activities of Rubinoboletus ballouii using bioassay-guided fractionation”, Poster presentation in “The 8th International Postgraduate Symposium on Chinese Medicine 2012”, August 16, 2012, Hong Kong.

  8. Li LF, Yue GGL, Chen BCL, Lau CBS, Han QB, Liu JK, Leung PC and Fung KP, “Investigations on the in vitro immunomodulatory activities of Rubinoboletus ballouii using bioassay-guided fractionation”, Poster presentation in “The 7th International Postgraduate Symposium on Chinese Medicine 2011”, August 11, 2011, Hong Kong.

  9. Li LF, Lau CBS, Yue GGL, Han QB, Liu JK, Leung PC and Fung KP, “Investigations on the in vitro anti-tumor activities of Rubinoboletus ballouii”, Poster presentation in “The 9th Meeting of Consortium for Globalization of Chinese Medicine (CGCM)”, August 23-25, 2010, Hong Kong.

  10. Li LF, Yue GGL, Lau CBS, Han QB, Liu JK, Leung PC and Fung KP, “Investigations on the in vitro immunomodulatory activities of Rubinoboletus ballouii using human peripheral blood mononuclear cells”, Poster presentation in “6th Hong Kong-Macau Postgraduate Symposium on Chinese Medicine 2010”, August 12, 2010.

  三、專利

  1. 李龍飛, 王琳琳, 刁梁輝, 黃春宇, 李玉葉, 連若純, 曾勇, 莫美蘭, 陳聰, 一組胚胎反覆種植失敗的生物標誌物、其篩選方法及應用. 申請號:202010363041.2,中國發明專利,2020.

  2. 李龍飛, 王琳琳, 刁梁輝, 黃春宇, 李玉葉, 連若純, 曾勇, 莫美蘭, 陳聰, 一組子宮內膜受容性的生物標誌物、其篩選方法及應用. 申請號:202010363060.5,中國發明專利,2020.

  3. 吳彤華, 李龍飛, 宋明哲, 葉麗君, 陳春媚, 曾勇, 一種 piRNA 及用於檢測和/或預測男性生殖功能障礙的試劑盒. 申請號:202010230867.1,中國發明專利,2020.

  4. 曹之憲, 李志傑, 李龍飛, 李明星, 腫瘤血管及M型巨噬細胞靶向肽及其用途.申請號:201711396421.0,中國發明專利,2017.

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