陳培林
陳培林

姓名:陳培林
職稱/頭銜:碩士
所屬科室:生殖科
從業年限:
技術專長:微流控芯片單細胞分析、微流控芯片微量生物分子分析及相關技術在輔助生殖胚胎無創性評估選擇的應用

個人簡介

  分析化學碩士,助理研究員。深圳中山泌尿外科醫院生殖臨床研究中心、錦欣醫療科技創新中心科研人員。主要研究方向包括:胚胎分泌蛋白評估胚胎髮育潛能的研究、微量蛋白定量檢測方法研究、微流控在輔助生殖中的應用研究。

  業務領域:

  主要從事利用微流控等技術評估胚胎質量,優化胚胎培養體系的研究。

  學術成果:

  主持或參加科研項目(課題)及人才計劃項目情況(按時間倒序排序):

  1、 中華醫學會生殖醫學青年醫師研究與發展項目,18010120741,一種無創行胚胎植入潛能評估方案-基於囊胚培養液誘導子宮內膜分泌蛋白群的定量分析,20190630-20210630,在研,參與。

  2、 國家自然科學基金委青年科學基金項目、21807072,人類胚胎內源性硫化氫的無創實時檢測及其調控胚胎髮育的作用機制研究,20190101-20211231,在研,參與。

  代表性研究成果和學術獎勵

  一、期刊論文

  1. 第一作者或通訊作者論文

  (1) Chen PL(#), Sun Q, Xiong F, Zhong HX, Yao ZH, Zeng Y(*). A method for the detection of hCG beta in spent embryo culture medium based on multicolor fluorescence detection from microfluidic droplets. Biomicrofluidics. 2020;14(2):024107.

  (2) 陳培林, 孫青, 熊風, 李觀貴, 鍾惠嫻, 萬才雲, 姚志鴻, 曾勇.不同來源冷凍復蘇精子ICSI后對囊胚培養結局的影響[J].生殖醫學雜誌,2019,(09):993-997.

  2.既非第一作者又非通訊作者論文

  (1) Zhong Huixian(#), Sun Qing(#), Chen Peilin, Xiong Feng, Li Guangui, Wan Caiyun, Yao Zhihong, Zeng Yong(*). Detection of IL-6, IL-10, and TNF-alpha level in human single-blastocyst conditioned medium using ultrasensitive Single Molecule Array platform and its relationship with embryo quality and implantation: a pilot study. J Assist Reprod Genet. 2020;37(7):1695-702.

  (2) Lu Li(#), Qingling Li(#), Peilin Chen, Zhongyi Li, Zhenzhen Chen, and Bo Tang(*). Consecutive Gated Injection-Based Microchip Electrophoresis for Simultaneous Quantitation of Superoxide Anion and Nitric Oxide in Single PC-12 Cells. Anal. Chem., 2016, 88, 930-936.

  (3) Qingling Li(#), Peilin Chen, Yuanyuan Fan, Xu Wang, Kehua Xu, Lu Li* and Bo Tang(*). Multi-Color Fluorescence Detection-Based Microfluidic Device for Single-Cell Metabolomics: Simultaneous Quantitation of Multiple Small Molecules in Primary Liver Cells. Anal. Chem., 2016, 88, 8610-8616.

  (4) Xiong F(#), Li GG, Sun Q, Chen PL, Wang Z, Wan CY, Yao ZH, Zhong H, Zeng Y(*). Obstetric and perinatal outcomes of pregnancies according to initial maternal serum HCG concentrations after vitrified-warmed single blastocyst transfer. Reprod Biomed Online. 2019;38(3):455-64.

  (5) Xiong F(#), Li GG, Sun Q, Wang SS, Wan CY, Chen PL, Yao ZH, Zhong HX, Zeng Y(*). Clinical outcomes after transfer of blastocysts derived from frozen-thawed cleavage embryos: a retrospective propensity-matched cohort study. Arch Gynecol Obstet. 2019;300(3):751-61.

  (6) Xiong F(#), Sun Q, Li GG, Chen PL, Yao ZH, Wan CY, Zhong HX, Zeng Y(*). Initial serum HCG levels are higher in pregnant women with a male fetus after fresh or frozen single blastocyst transfer: A retrospective cohort study. Taiwan J Obstet Gynecol. 2019;58(6):833-9.

  (7) Xiong F(#), Sun Q, Li GG, Yao ZH, Chen PL, Wan CY, Zhong HX, Zeng Y(*). Association between the number of top-quality blastocysts and live births after single blastocyst transfer in the first fresh or vitrified-warmed IVF/ICSI cycle. Reprod Biomed Online. 2020;40(4):530-7.

  (8) Xiong F(#), Wang SS, Sun Q, Ye L, Yao ZH, Chen PL, Wan CY, Zhong HX, Zeng Y(*). A visualized clinical model predicting good quality blastocyst development in the first IVF/ICSI cycle. Reprod Biomed Online. 2020;41(5):807-17.

  (9) Xiong F(#), Yao ZH, Chen PL, Sun Q, Zhong HX, Wan C, Zeng Y(*). Comparative secretome profile analysis of cultured immortalized human endometrial stromal cells supplemented with implanted versus nonimplanted blastocyst-conditioned medium: A preliminary analysis. J Obstet Gynaecol Res. 2020;46(9):1809-18.

  二、授權專利

  (1) 唐波,李清嶺,李璐,陳培林,一種用於單細胞電泳芯片的雙激光誘導熒光多色檢測器,2019.07.23,國家發明專利,ZL 2016 1 0069047.2。